Neal Page is an advertising executive who just wants to fly home to Chicago to spend Thanksgiving with his family. But all Neal Page gets is misery. Misery named Del Griffith — a loud mouthed, but nevertheless lovable, salesman who leads Neal on a cross-country, wild goose chase that keeps Neal from tasting his turkey.
Bob’s lazy, carefree brother, Buck (John Candy). While he immediately gets along with the two younger children (Gaby Hoffman, Macaulay Culkin), Buck must change his bachelor lifestyle if he wants to be a responsible caregiver for the angst-filled teenager, Tia (Jean Louisa Kelly).